School of Crystallography, Birkbeck College, University of London |
Aims
For proper understanding of biological function a detailed knowledge of the three-dimensional structure of biological macromolecules and their interactions with ligands and the aqueous environment is required. Protein crystallography (or structural molecular biology) is powerful in that it can identify the residues determining substrate specificity and interactions with other macromolecules at the atomic level, allowing the targeting of site-directed mutagenesis experiments and the design of selective inhibitors, so important in industry. Protein crystallography is no longer solely the domain of the mathematician and physicist, but that of the biologically orientated scientist. It is now a very multidisciplinary technique which has overlap with biochemistry, molecular biology, bioinformatics, biophysics and organic chemistry. The web course is therefore ideally suited for students of these disciplines who want to know in more detail (mainly non-mathematical) how structures are determined, how the quality of coordinates should be judged, and how crystallographic papers should be assessed. It will also appeal to those who envisage a further career in this exciting and rapidly expanding field, especially also in the pharmaceutical industry.
Course Organisation and Objectives
The Advanced Certificate in Protein Crystallography on the Web, is a tutor-assisted, university-level, accredited course, hosted by the School of Crystallography, Birkbeck College. Successful students receive the award of an Institution Certificate.
The course consists of 3 units taught annually. All teaching material will be delivered on the Internet.
Unit 1: Fundamentals of Protein Structure and X-Ray Crystallography
This unit has as general objectives
Unit 2: Protein Crystallography
This unit has as general objectives
Unit 3: Project
This unit has as general objective to apply, improve and test the skills learned in units 1 and 2 on two projects
Specific objectives are listed in the syllabus / timetable.
Academic Requirements
The University of London requires as minimum eligibility requirements
BSc or equivalent (for EU or non-EU overseas
students) in computing, mathematics, biology, chemistry or physics.
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for more details.
Technical Requirements
Students will be expected to have a standard PC or workstation
and access to the Internet.
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for more details.
Workload and Course Attendance
Language
The language of the course is English combined with Hypertext Markup Language (HTML) for the delivery
and receipt of course material, assignments, and projects.
Assessment
The course leads to the award of an Advanced Certificate from
Birkbeck College, University of London. Each student is
assessed by a combination of the course work assignments submitted in Terms 1 and 2,
the projects
submitted in Term 3 (with possibly short oral examination)
and an unseen final written examination in Term 3.
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about American credit equivalent.
Course Organiser and Admissions Tutor
Course Tutors
Dr Jeremy K Cockcroft
Course Administrator
Technical Consultant
Enrolment
Dr Ian J Tickle
Professor David S Moss
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