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Advanced  Certificate  in  Protein  Crystallography  on  the  Web 
Timetable  Lectures  03/04 

School of CrystallographyBirkbeck College
University of London



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Normally lectures will be made available at the beginning of the week. Week numbers are sequential per term. Each TERM roughly coincides with a particular unit. There will be deviations for a few individual lectures, in order to pace delivery of more difficult subjects. Some "weeks" in Terms 1 and 2 have a release which is intended to be studied over a 2-week period. "Weeks" and "Lectures" in Term 3 are only nominal, as the projects are self-paced.

Official start date November 3rd.
Please complete enrolment including payment by Monday December 1st. Closure date for applications Monday December 1st.

TERM 1 (Unit 1: Fundamentals of Protein Structure and X-ray Crystallography)
WeekDateLecture TopicLecturer responsible
1-2 03-11 Introduction & Web Authoring Overview of Protein Crystallography & Bioinformatics (RasMol, Mime, HTML, Images, BioMOO) TEB
1-2 03-11 Protein Structure I Primary Structure & Amino Acid and Peptide Bond Geometry TEB
3 17-11 Protein Structure II Non-Covalent (Non-Bonded) Interactions TEB
4 24-11 X-Ray Diffraction I Diffraction Theory (Scattering, Unit Cell, Braggs Law, Reciprocal Space, Indices, Structure Factor) TEB
5 01-12 Protein Structure III Secondary Structure & Super Secondary Structure TEB
Christmas Break
6-7 6-1 X-Ray Diffraction II Fourier Transforms (Synthesis, Analysis, Convolutions, Correlations) TEB
8 19-1 Protein Structure IV Tertiary Structure & Quaternary Structure (Point Groups) TEB, JKC
9 26-1 Symmetry I Symmetry Operations (Rotational, Translational, Screw, Symbols, Unit Cell) JKC, TEB
10-11 2-2 Symmetry II Point Groups (Enantiomorphic, Polar, Laue Classes) JKC, TEB
12 16-2 Protein Crystallography I Protein Crystallisation TEB
Break
TERM 2 (Unit 2: Protein Crystallography)
WeekDateLecture TopicLecturer responsible
1-2 8-3 Symmetry III Space Groups (Enantiomorphic, Asymmetric Unit, P21, P212121) JKC, TEB
3 22-3 Protein Crystallography II and the CCP4 GUI X-Rays, X-Ray Sources (Laboratory, Synchrotron) & X-Ray Detectors (Image Plate, CCD) and and introduction to the CCP4 GUI. TEB, JKC
4 29-3 Protein Crystallography III Data Collection (Oscillation Method) & Cryocrystallography TEB
5-6 5-4 Symmetry IV & Protein Crystallography IV Extinctions, Space Group Determination & Data Processing TEB, JKC
Easter Break
7 26-4 Protein Crystallography V & X-Ray Diffraction III Molecular Replacement (Rotation Function, Translation Function), Patterson TEB
8 3-5 Protein Crystallography VI Isomorphous Replacement, Patterson NQM
9-10 10-5 Protein Crystallography VII & X-Ray Diffraction IV MAD, Anomalous Diffraction NQM,
11 24-5 Protein Crystallography VIII Density Modification NQM
12 31-5 Protein Crystallography IX Electron Density Map, Modelling & Refinement NQM
12 14-6 Protein Crystallography X Validation & PDB NQM
TERM 3 (Unit 3: Project)
WeekDate Lecture TopicLecturer responsible
1 21-6 Protein Crystallography XI & Project A Papers & Understanding Crystallographic Results
Project A Paper Abstract
TEB
1 23-6 Project B Project B Molecular Replacement TEB
1-10 Months 6/7/8/9/10 Project A & B Project Work TEB
Break
Late September WRITTEN EXAMINATIONS
Break
October SUBMISSION OF PROJECT WORK
by ChristmasCERTIFICATES AWARDED



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