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Advanced  Certificate  in  Protein  Crystallography  on  the  Web 
Syllabus /Nominal  Timetable 

School of CrystallographyBirkbeck College
University of London

Normally lectures will be made available at the beginning of the week. Week numbers are sequential per term. Each TERM roughly coincides with a particular unit. There will be deviations for a few individual lectures, in order to pace delivery of more difficult subjects. Some "weeks" in Terms 1 and 2 have a release which is intended to be studied over a 2-week period. "Weeks" and "Lectures" in Term 3 are only nominal, as the projects are self-paced.

TERM 1 (Unit 1: Fundamentals of Protein Structure and X-ray Crystallography)
WeekLecture TopicLecturer responsible
1 Introduction & Web Authoring Overview of Protein Crystallography & Bioinformatics (RasMol, Mime, HTML, Images, BioMOO) NQM
2 Protein Structure I Primary Structure & Amino Acid and Peptide Bond Geometry NQM
3 Protein Structure II Non-Covalent (Non-Bonded) Interactions NQM
4 X-Ray Diffraction I Diffraction Theory (Scattering, Unit Cell, Braggs Law, Reciprocal Space, Indices, Structure Factor) NQM
5 Protein Structure III Secondary Structure & Super Secondary Structure NQM
6 X-Ray Diffraction II Fourier Transforms (Synthesis, Analysis, Convolutions, Correlations) NQM
7 Protein Structure IV Tertiary Structure & Quaternary Structure (Point Groups) NQM
8 Symmetry I Symmetry Operations (Rotational, Translational, Screw, Symbols, Unit Cell) JKC, NQM
9 Symmetry II Point Groups (Enantiomorphic, Polar, Laue Classes) JKC, NQM
10 Symmetry III Space Groups (Enantiomorphic, Asymmetric Unit, P21, P212121) JKC, NQM
TERM 2 (Unit 2: Protein Crystallography)
WeekLecture TopicLecturer responsible
1 Protein Crystallography I Protein Crystallisation NQM
2 Protein Crystallography II X-Rays, X-Ray Sources (Laboratory, Synchrotron) & X-Ray Detectors (Image Plate, CCD) NQM, JKC
3 Protein Crystallography III Data Collection (Oscillation Method) & Cryocrystallography NQM
4 Symmetry IV & Protein Crystallography IV Extinctions, Space Group Determination & Data Processing NQM, JKC
5 Protein Crystallography V & X-Ray Diffraction III Molecular Replacement (Rotation Function, Translation Function), Patterson NQM
6 Protein Crystallography VI Isomorphous Replacement, Patterson NQM
7 Protein Crystallography VII & X-Ray Diffraction IV MAD, Anomalous Diffraction NQM, NQM
8 Protein Crystallography VIII Density Modification NQM
9 Protein Crystallography IX Electron Density Map, Modelling & Refinement NQM
10 Protein Crystallography X Validation & PDB NQM
TERM 3 (Unit 3: Project)
Week Lecture TopicLecturer responsible
1 Protein Crystallography XI & Project A Papers & Understanding Crystallographic Results
Project A Paper Abstract
2 Project B Project B Molecular Replacement NQM
3 Project A & B Project Work NQM
4 Project A & B Project Work NQM
5 project A & B Project Work NQM
6 Project A & B Project Work NQM
7 Project A & B Project Work NQM
8 Project A & B Project Work NQM
9 Project A & B Project Work NQM
10 Project A & B Project Work NQM

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