School of Crystallography,
Birkbeck College,
University of London
Normally lectures will be made available at the beginning of the week. Week numbers are sequential per term. Each TERM roughly coincides with a particular unit. There will be deviations for a few individual lectures, in order to pace delivery of more difficult subjects. Some "weeks" in Terms 1 and 2 have a release which is intended to be studied over a 2-week period. "Weeks" and "Lectures" in Term 3 are only nominal, as the projects are self-paced.
TERM 1 (Unit 1: Fundamentals of Protein Structure and X-ray Crystallography) | ||||
---|---|---|---|---|
Week | Lecture | Topic | Lecturer responsible | |
November | ||||
1 | Introduction & Web Authoring | Overview of Protein Crystallography & Bioinformatics (RasMol, Mime, HTML, Images, BioMOO) | NQM | |
2 | Protein Structure I | Primary Structure & Amino Acid and Peptide Bond Geometry | NQM | |
3 | Protein Structure II | Non-Covalent (Non-Bonded) Interactions | NQM | |
4 | X-Ray Diffraction I | Diffraction Theory (Scattering, Unit Cell, Braggs Law, Reciprocal Space, Indices, Structure Factor) | NQM | |
5 | Protein Structure III | Secondary Structure & Super Secondary Structure | NQM | |
6 | X-Ray Diffraction II | Fourier Transforms (Synthesis, Analysis, Convolutions, Correlations) | NQM | |
7 | Protein Structure IV | Tertiary Structure & Quaternary Structure (Point Groups) | NQM | |
8 | Symmetry I | Symmetry Operations (Rotational, Translational, Screw, Symbols, Unit Cell) | JKC, NQM | |
9 | Symmetry II | Point Groups (Enantiomorphic, Polar, Laue Classes) | JKC, NQM | |
10 | Symmetry III | Space Groups (Enantiomorphic, Asymmetric Unit, P21, P212121) | JKC, NQM | |
Break | ||||
TERM 2 (Unit 2: Protein Crystallography) | ||||
Week | Lecture | Topic | Lecturer responsible | |
1 | Protein Crystallography I | Protein Crystallisation | NQM | |
2 | Protein Crystallography II | X-Rays, X-Ray Sources (Laboratory, Synchrotron) & X-Ray Detectors (Image Plate, CCD) | NQM, JKC | |
3 | Protein Crystallography III | Data Collection (Oscillation Method) & Cryocrystallography | NQM | |
4 | Symmetry IV & Protein Crystallography IV | Extinctions, Space Group Determination & Data Processing | NQM, JKC | |
5 | Protein Crystallography V & X-Ray Diffraction III | Molecular Replacement (Rotation Function, Translation Function), Patterson | NQM | |
6 | Protein Crystallography VI | Isomorphous Replacement, Patterson | NQM | |
7 | Protein Crystallography VII & X-Ray Diffraction IV | MAD, Anomalous Diffraction | NQM, NQM | |
8 | Protein Crystallography VIII | Density Modification | NQM | |
9 | Protein Crystallography IX | Electron Density Map, Modelling & Refinement | NQM | |
10 | Protein Crystallography X | Validation & PDB | NQM | |
Break | ||||
TERM 3 (Unit 3: Project) | ||||
Week | Lecture | Topic | Lecturer responsible | |
1 | Protein Crystallography XI & Project A | Papers & Understanding Crystallographic Results
Project A Paper Abstract | NQM | |
2 | Project B | Project B Molecular Replacement | NQM | |
3 | Project A & B | Project Work | NQM | |
4 | Project A & B | Project Work | NQM | |
5 | project A & B | Project Work | NQM | |
6 | Project A & B | Project Work | NQM | |
7 | Project A & B | Project Work | NQM | |
8 | Project A & B | Project Work | NQM | |
9 | Project A & B | Project Work | NQM | |
10 | Project A & B | Project Work | NQM | |
Break | ||||
September | WRITTEN EXAMINATIONS | |||
Break | ||||
October | SUBMISSION OF PROJECT WORK | |||
by Christmas | CERTIFICATES AWARDED | |||