School of Crystallography,
Birkbeck College,
University of London
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Normally lectures will be made available at the beginning of the week. Week numbers are sequential per term. Each TERM roughly coincides with a particular unit. There will be deviations for a few individual lectures, in order to pace delivery of more difficult subjects. Some "weeks" in Terms 1 and 2 have a release which is intended to be studied over a 2-week period. "Weeks" and "Lectures" in Term 3 are only nominal, as the projects are self-paced.
Official start date 11 November.
Please complete enrolment including payment by Monday December 1st.
Closure date for applications Monday December 1st.
| TERM 1 (Unit 1: Fundamentals of Protein Structure and X-ray Crystallography) | ||||
|---|---|---|---|---|
| Week | Date | Lecture | Topic | Lecturer responsible |
| 1-2 | 11-11 | Introduction & Web Authoring | Overview of Protein Crystallography & Bioinformatics (RasMol, Mime, HTML, Images, BioMOO) | HPCD |
| 1-2 | 11-11 | Protein Structure I | Primary Structure & Amino Acid and Peptide Bond Geometry | HPCD |
| 3 | 25-11 | Protein Structure II | Non-Covalent (Non-Bonded) Interactions | HPCD |
| 4 | 2-12 | X-Ray Diffraction I | Diffraction Theory (Scattering, Unit Cell, Braggs Law, Reciprocal Space, Indices, Structure Factor) | HPCD |
| 5 | 9-12 | Protein Structure III | Secondary Structure & Super Secondary Structure | HPCD |
| Christmas Break | ||||
| 6-7 | 6-1 | X-Ray Diffraction II | Fourier Transforms (Synthesis, Analysis, Convolutions, Correlations) | HPCD |
| 8 | 20-1 | Protein Structure IV | Tertiary Structure & Quaternary Structure (Point Groups) | NQM, JKC |
| 9 | 27-1 | Symmetry I | Symmetry Operations (Rotational, Translational, Screw, Symbols, Unit Cell) | JKC, NQM |
| 10-11 | 3-2 | Symmetry II | Point Groups (Enantiomorphic, Polar, Laue Classes) | JKC, NQM |
| 12 | 17-2 | Protein Crystallography I | Protein Crystallisation | NQM |
| Break | ||||
| TERM 2 (Unit 2: Protein Crystallography) | ||||
| Week | Date | Lecture | Topic | Lecturer responsible |
| 1-2 | 10-3 | Symmetry III | Space Groups (Enantiomorphic, Asymmetric Unit, P21, P212121) | JKC, NQM |
| 3 | 24-3 | Protein Crystallography II | X-Rays, X-Ray Sources (Laboratory, Synchrotron) & X-Ray Detectors (Image Plate, CCD) | NQM, JKC |
| 4 | 31-3 | Protein Crystallography III | Data Collection (Oscillation Method) & Cryocrystallography | NQM |
| 5-6 | 7-4 | Symmetry IV & Protein Crystallography IV | Extinctions, Space Group Determination & Data Processing | NQM, JKC |
| Easter Break | ||||
| 7 | 6-5 | Protein Crystallography V & X-Ray Diffraction III | Molecular Replacement (Rotation Function, Translation Function), Patterson | NQM |
| 8 | 12-5 | Protein Crystallography VI | Isomorphous Replacement, Patterson | NQM |
| 9-10 | 19-5 | Protein Crystallography VII & X-Ray Diffraction IV | MAD, Anomalous Diffraction | NQM, NQM |
| 11 | 2-6 | Protein Crystallography VIII | Density Modification | NQM |
| 12 | 9-6 | Protein Crystallography IX | Electron Density Map, Modelling & Refinement | NQM |
| 12 | 16-6 | Protein Crystallography X | Validation & PDB | NQM |
| TERM 3 (Unit 3: Project) | ||||
| Week | Date | Lecture | Topic | Lecturer responsible |
| 1 | 23-6 | Protein Crystallography XI & Project A | Papers & Understanding Crystallographic Results
Project A Paper Abstract | NQM |
| 1 | 23-6 | Project B | Project B Molecular Replacement | NQM |
| 1-10 | Months 6/7/8/9/10 | Project A & B | Project Work | NQM |
| Break | ||||
| Late September | WRITTEN EXAMINATIONS | |||
| Break | ||||
| October | SUBMISSION OF PROJECT WORK | |||
| by Christmas | CERTIFICATES AWARDED | |||
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